略歴

1982年　大阪市立大学大学院理学研究科化学専攻後期課程修了（理学博士）

1983年　米国コーネル大学化学科博士研究員

　　　　応用生化学研究所研究員

　　　　（財）蛋白質研究奨励会研究員

　　　　（株）日本チバガイギー国際科学研究所を経て

1997年　東京理科大学計算科学フロンティア研究センター助教授

1999年　倉敷芸術科学大学産業科学技術学部機能物質化学科教授

2004年　より現職

 

専門分野

計算化学、理論化学、生物物理学

 

　　これまでの代表的論文 （より最近の論文についてはこちら）

The Functional Residues Shown by a Hypothetical 3D Structure of
Silkworm Eclosion Hormone.
Norihisa Fujita, Takashi Maekawa, Satoshi Ohta and Takeshi Kikuchi
Protein Engineering, 11, 769-773 (1998)

The Stabilized Structural Array of Two HMG1/2-boxes Endowed by
Linker Sequence between Them is Requisite for the Effective Binding
of HMG1.
Kouhei Saito, Takeshi Kikuchi, Hitoshi Sshirakawa and Michiteru
Yoshida
Journal of Biochemistry, 125, 399-405 (1999)

Study of Protein Fluctuation with an Effective Inter Ca Atomic
Potential Derived from Average Distance between Amino Acids in
Proteins.
Takeshi Kikuchi
Journal of Computational Chemistry, 20, 713-719 (1999)

A CoMFA Analysis with Conformational Propensity: An Attempt to
Analyze the SAR of a Set of Molecules with Different Conformational
Flexibility Using a 3D-QSAR Method.
Keigo Gohda, Ichiro Mori, Daisaku Ohta and Takeshi Kikuchi
Journal of Computer-Aided Molecular Dsign, 14, 265-275 (2000).

Kinetics of a Finite One-Dimensional Spin System As a Model for
Protein Folding.
Takeshi Kikuchi
Biophysical Chemistry, 85, 93-100 (2000).

Molecular Simulation of the Conformational Change for Humen Serum
Transferrin Induced by Iron Binding. Implication of the Mechanism of
Binding to Its Receptor.
Hirofumi Yajima, Tetsuya Sakajiri, Takeshi Kikuchi, and Tadahiro
Ishii
Journal of Protein Chemistry, 19, 215 (2000)

Contact maps derived from the statistics of average distances
between residues in proteins.   Application to the prediction of
structures and active sites of proteins and peptides.
Takeshi Kikuchi

Recent Research Developments in Protein Engineering (Research
Signpost, Kerala, India)  S. G. Pandalai ed., Vol. 2, p. 1-48 (2002)

Analysis of the Differences in the Folding Kinetics of Structurally
Homologous Proteins Based on Predictions of the Gross Features of
Residue Contacts
Takehiro Ichimaru and Takeshi Kikuchi
Proteins, 51, 515 (2003)
　
“Analysis of the differences of the folding kinetics of structurally homologous proteins based on the predictions of the gross feature of the residue contacts.”
Takehiro Ichimaru and Takeshi Kikuchi, Proteins: Structure, Function and Genetics, 51, 515-530 (2003).

“Prediction of folding pathway and kinetics among plant hemoglobins by using an average distance map method.” Shunsuke Nakajima, Emma Álvarez-Salgado, Takeshi Kikuchi and Raúl Arredondo-Peter
Proteins: Structure, Function and Bioinformatics, 61, 500-506 (2005).

“Analysis of the differences in the folding mechanisms of c-type lysozymes based on contact maps constructed with interresidue average distances.” Shunsuke Nakajima and Takeshi Kikuchi, Journal of Molecular Modeling, 13, 587-594 (2007)

“Analysis of 3D structural differences in the IgG-binding domains based on the interresidue average-distance statistics.” Takeshi Kikuchi, Amino Acids, 5, 541-549 (2008).

“Spin correlations in a no frustrated one-dimensional spin system and the formation of the ground state as a model of protein folding.”
Takeshi Kikuchi, Physica A: Statistical Mechanics and its Applications, 388, 129-136 (2009).