Faculty of
Sport and Health Science
Ritsumeikan Univercity

2012年以前

• (1) Otsuki T, Shimizu K, Iemitsu M, Kono I. Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants. Nutr J 11:103, 2012.

  (2)Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. Nutrition 28: 1122-1126, 2012.

  (3)Sato K, Iemitsu M, Aizawa K, Mesaki N, Ajisaka R, Fujita S. DHEA administration and exercise training improves insulin resistance in obese rats. Nutr Metab 9: 47, 2012.

  (4)Sanada K, Iemitsu M, Murakami H, Gando Y, Kawano H, Kawakami R, Tabata I, Miyachi M. Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women. Eur J Clin Nutr 66: 1093-1098, 2012.

  (5)Fuku N, Murakami H, Iemitsu M, Sanada K, Tanaka M, Miyachi M. Mitochondrial macrohaplogroup associated with muscle power in healthy adults. Int J Sports Med 33: 410-414, 2012.

  (6) Murakami H, Iemitsu M, Sanada K, Gando Y, Ohmori Y, Kawakami R, Sasaki S, Tabata I, Miyachi M. Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype.  Eur J Appl Physiol 111: 2997-3005, 2011.

  (7) Ogura Y Iemitsu M, Naito H, Kakigi R, Kakehashi C, Maeda S, Akema T.  Single bout of running exercise changes LC3-II expression in rat cardiac muscle.  Biochem Biophys Res Commun 414: 756-760, 2011.

  (8) Aizawa K, Iemitsu M, Maeda S, Mesaki N, Ushida T, Akimoto T.  Endurance exercise training enhances local sex steroidogenesis in skeletal muscle. Med Sci Sports Exerc 43: 2072-2080, 2011.

  (9) Otsuki T, Shimizu K, Iemitsu M, Kono I.  Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study.  Nutr J 10: 19, 2011.

  (10) Zempo H, Tanabe K, Murakami H, Iemitsu M, Maeda S, Kuno S. Age differences in the relation between ACTN3 R577X polymorphism and thigh-muscle cross-sectional area in women.  Genet Test Mol Biomarkers 15: 639-643, 2011.

  (11) Park JH, Aizawa K, Iemitsu M, Sato K, Akimoto T, Agata U, Maeda S, Ezawa I, Omi N.  DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats.  Calcif Tissue Int 89: 105-110, 2011.

  (12) Katayama K, Ishida K, Iwamoto E, Iemitsu M, Koike T, Saito M..  Hypoxia augments muscle sympathetic neural response to leg cycling.  Am J Physiol Regul Integr Comp Physiol 301: R456-R464, 2011.

  (13) Sato K, Iemitsu M, Aizawa K, Mesaki N, Fujita S.  Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats..  Am J Physiol Endocrinol Metab 301: E274-E280, 2011.

  (14) Sanada K, Iemitsu M, Murakami H, Tabata I, Yamamoto K, Gando Y, Suzuki K, Higuchi M, Miyachi M.  PPAR{gamma}2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness.  Physiol Genomics 43: 103-109, 2011.

  (15) Iemitsu M, Murakami H, Sanada K, Yamamoto K, Kawano H, Gando Y, Miyachi M.  Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults.  Physiol Genomics 42: 259-265, 2010.

  (16) Zempo H, Tanabe K, Murakami H, Iemitsu M, Maeda S, Kuno S.  ACTN3 polymorphism affects thigh muscle area.  Int J Sports Med 31: 138-142, 2010.

  (17) Aizawa K, Iemitsu M, Maeda S, Otsuki T, Sato K, Ushida T, Mesaki N, Akimoto T.  Acute exercise activates local bioactive androgen metabolism in skeletal muscle.  Steroids 75: 219-223, 2010.

  (18) Matsuo T, Nakata Y, Katayama Y, Iemitsu M, Maeda S, Okura T, Kim MK, Ohkubo H, Hotta K, Tanaka K.  PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction.  Obesity 17: 1924-1931, 2009.

  (19) Yamamoto K, Kawano H, Gando Y, Iemitsu M, Murakami H, Sanada K, Tanimoto M, Ohmori Y, Higuchi M, Tabata I, Miyachi M.  Poor trunk flexibility is associated with arterial stiffening.  American Journal of Physiology Heart and Circulatory Physiology 297: H1314-H1418, 2009.

  (20) Sato K, Iemitsu M, Aizawa K, Ajisaka R.  DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats.  Acta Physiologica 197: 217-225, 2009.

  (21) Misono M, Maeda S, Iemitsu M, Nakata Y, Otsuki T, Sugawara J, Zempo H, Yoshizawa M, Miyaki A, Kuno S, Matsuda M, Ajisaka R.  Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension.  Journal of Hypertension 27: 1377-1383, 2009.

  (22) Park JH, Omi N, Iemitsu M, Maeda S, Kitajima A, Nosaka T, Ezawa I.  Relationship between arterial calcification and bone loss in a new combined model rat by ovariectomy and vitamin D(3) plus nicotine.  Calcified Tissue International 83: 192-201, 2008.

  (23) Iemitsu M, Shimojo N, Maeda S, Irukayama-Tomobe Y, Sakai S, Ohkubo T, Tanaka Y, Miyauchi T.  The benefit of medium-chain triglyceride (MCT) therapy on cardiac function of SHR is associated with reversal of metabolic and signaling alterations.  American Journal of Physiology Heart and Circulatory Physiology 295: H136-H144 2008.

  (24) Iemitsu M, Maeda S, Otsuki T, Sugawara J, Kuno S, Ajisaka R, Matsuda M.  Arterial Stiffness, Physical Activity, and Atrial Natriuretic Peptide Gene Polymorphism in Older Subjects.  Hypertension Research 31: 767-774, 2008.

  (25) Sato K, Iemitsu M, Aizawa K, Ajisaka R.  Testosterone and DHEA activates the glucose metabolism-related signalling pathway in skeletal muscle.  American Journal of Physiology Endocrinology and Metabolism 294: E961-E968, 2008.

  (26) Saito Y, Iemitsu M, Otsuki T, Maeda S, Ajisaka R.  Gender Differences in Brachial Blood Flow during Fatiguing Intermittent Handgrip.  Medicine & Science in Sports & Exercise 40: 684-690, 2008.

  (27) Aizawa K, Iemitsu M, Otsuki T, Maeda S, Miyauchi T, Mesaki N.  Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats.  Journal of Applied Physiology 104: 67-74, 2008.

  (28) Park JH, Iemitsu M, Maeda S, Kitajima A, Nosaka T, Omi N.  Voluntary running exercise attenuates the progression of endothelial dysfunction and arterial calcification in ovariectomized rats.  Acta Physiologica 193: 47-55, 2008.

  (29) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Systemic arterial compliance, systemic vascular resistance, and effective arterial elastance during exercise in endurance-trained men.  American Journal of Physiology Regulatory, Integrative and Comparative Physiology 295:,R228-R235, 2008.

  (30) Hayashi K, Maeda S, Iemitsu M, Otsuki T, Sugawara J, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Estrogen receptor-alpha genotype affects exercise-related reduction of arterial stiffness.  Medicine & Science in Sports & Exercise 40: 252-257, 2008.

  (31) Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M.  Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.  Molecular and Cellular Biology 28: 1285-1297, 2008.

  (32) Huang H, Tada Iida K, Murakami H, Saito Y, Otsuki T, Iemitsu M, Maeda S, Sone H, Kuno S, Ajisaka R.  Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training.  Endocrine Journal 54: 879-886, 2007.

  (33) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Relationship between arterial stiffness and athletic training programs in young adult men.  American Journal of Hypertension 20: 967-973, 2007.

  (34) Hayashi K, Maeda S, Iemitsu M, Otsuki T, Sugawara J, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Sex differences in the relationship between estrogen receptor alpha gene polymorphisms and arterial stiffness in older humans.  American Journal of Hypertension 20: 650-656, 2007.

  (35) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Sugawara J, Ajisaka R, Miyauchi T.  Postexercise heart rate recovery accelerates in strength-trained athletes.  Medicine & Science in Sports & Exercise 39: 365-370, 2007.

  (36) Jesmin S, Zaedi S, Shimojo N, Iemitsu M, Masuzawa K, Yamaguchi N, Mowa CN, Maeda S, Hattori Y, Miyauchi T.  Endothelin Antagonism Normalizes VEGF Signaling and Cardiac Function in STZ-Induced Diabetic Rat Hearts.  American Journal of Physiology Endocrinology and Metabolism 292: E1030-E1040, 2007.

  (37) Aizawa K, Iemitsu M, Maeda S, Jesmin S, Otsuki T, Mowa CN, Miyauchi T, Mesaki N.  Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats.  American Journal of Physiology Endocrinology and Metabolism 292: E577-E584, 2007.

  (38) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men.  American Journal of Physiology Heart and Circulatory Physiology 292: H786-H791, 2006.

  (39) Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T.  Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts.  American Journal of Physiology Heart and Circulatory Physiology 291: H1290-H1298, 2006.

  (40) Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Jesmin S, Kuno S, Ajisaka R, Miyauchi T, Matsuda M.  Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in the older subjects.  Hypertension 47: 928-936, 2006.

  (41) Iemitsu M, Maeda S, Jesmin S, Otsuki T, Kasuya Y, Miyauchi T.  Activation of multiple mitogen-activated protein kinase (MAPK) signaling pathways in rat heart by exercise.  Journal of Applied Physiology 101: 151-163, 2006.

  (42) Iemitsu M, Maeda S, Miyauchi T, Kuno S, Murakami K, Matsuda M.  Gene Expression Profiling of Exercise-induced Cardiovascular Adaptations: Molecular Insight from Microarray Analyses.    International Journal of Sport and Health Science 4: 451-459, 2006.

  (43) Otsuki T, Maeda S, Iemitsu M, Jesmin S, Miyauchi T.  Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types.  Japanese Journal of Physical Fitness Sports and Medisine 55: S65-S70, 2006.

  (44) Maeda S, Jesmin S, Iemitsu M, Otsuki T, Matsuo T, Ohkawara K, Nakata Y, Tanaka, K Goto K, Miyauchi T.  Weight loss reduces plasma endothelin-1 concentration in obese men.  Experimental Biology and Medicine 231: 1044-1047, 2006.

  (45) Ueno M, Kakinuma Y, YuhkiK, Murakoshi N, Iemitsu M, Miyauchi T, Yamaguchi I.  Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.  Journal of Pharmacology Science 101: 151-158, 2006.

  (46) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Goto K, Miyauchi T.  Effects of athletic strength and endurance exercise training in young humans on plasma endothelin-1 concentration and arterial distensibility.  Experimental Biology and Medicine 231: 789-793, 2006.

  (47) Maeda S, Otsuki T, Iemitsu M, Kamioka M, Sugawara J, Kuno S, Ajisaka R, Tanaka H.  Effects of leg resistance training on arterial function in older men.  British Journal of Sports Medicine 40: 867-869, 2006.

  (48) Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Contribution of systemic arterial compliance and systemic vascular resistance to effective arterial elastance changes during exercise in humans.  Acta Physiologica 188: 15-20, 2006.

  (49) Iemitsu M, Maeda S, Otsuki T, Goto K, Miyauchi T.  Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy.  Experimental Biology and Medicine 231: 871-875, 2006.

  (50) Iemitsu M, Maeda S, Miyauchi T, Matsuda M, Tanaka H.  Gene Expression Profiling of Exercise-Induced Cardiac Hypertrophy in rats.  Acta Physiologica Scandinavica 185: 259-270, 2005.

  (51) Maeda S, Iemitsu M, Miyauchi T, Kuno S, Matsuda M, Tanaka H.  Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses.  Medicine & Science in Sports & Exercise 37: 1710-1716, 2005.

  (52) Maeda S, Iemitsu M, Subrina J, Miyauchi T.  Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats.  Acta Physiologica Scandinavica 185: 79-86, 2005.

  (53) Sun Y, Iemitsu M, Shimojo N, Miyauchi T, Amamiya M, Sumi D, Hayashi T, Sun G, Shimojo N, Kumagai Y.  2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats.  Archives Toxicology 16: 1-6, 2005.

  (54) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Matsuda M, Yamaguchi I.  Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats.  American Journal of Physiology Heart and Circulatory Physiology 286: H1696-H1705, 2004.

  (55) Iemitsu M, Miyauchi T, Maeda S, Matsuda M, Yamaguchi I.  Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats.   Journal of Cardiovascular Pharmacology 44: S447-S450, 2004.

  (56) Maeda S, Iemitsu M, Miyauchi T, Goto K.  Exercise-induced tissue-specific change in gene expression of endothelin-1.   Journal of Cardiovascular Pharmacology 44: S336-S340, 2004.

  (57) Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Goto K, Yamaguchi I, Matsuda M.  Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise.  American Journal of Physiology Endocrinology and Metabolism 286: E609-E614, 2004.

  (58) Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I.  Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH₂-terminal kinase pathway.  Circuration 109: 904-910, 2004.

  (59) Shimojo N, Miyauchi T, Iemitsu M, Irukayama-Tomobe Y, Maeda S, Ohkubo T, Tanaka Y, Goto K, Yamaguchi I.  Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy, and expression of endothelin-1 mRNA and other genes.  Journal of Cardiovascular Pharmacology 44: S181-S185, 2004.

  (60) Maeda S, Tanabe T, Otsuki T, Sugawara J, Iemitsu M, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Moderate regular exercise increases basal production of nitric oxide in elderly women.    Hypertension Research 27: 947-953, 2004.

  (61) Fujimori A, Miyauchi T, Sakai S, Yuyama H, Iemitsu M, Sanagi M, Sudoh K, Goto K, Shikama H, Yamaguchi I.  YM598, an orally active ETA receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction.  Journal of Cardiovascular Pharmacology 44: S354-S357, 2004.

  (62) Miyauchi T, Fujimori A, Maeda S, Iemitsu M, Sakai S, Shikama H, Tanabe T, Matsuda M, Goto K, Yamaguchi I. Chronic Administration of an Endothelin-A Receptor Antagonist Improves Exercise Capacity in Rats with Myocardial Infarction-induced Congestive Heart Failure.  Journal of Cardiovascular Pharmacology 44: S64-S67, 2004.

  (63) Maeda S, Miyauchi T, Iemitsu M, Sugawara J, Nagata Y, Goto K.  Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans.  Journal of Cardiovascular Pharmacology 44: S443-S446, 2004.

  (64) Sugawara J, Tanabe T, Miyachi M, Yamamoto K, Takahashi K, Iemitsu M, Otsuki T, Satoru H, Maeda S, Ajisaka R, Matsuda M.  Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method.  Acta Physiologica Scandinavica 179: 361-366, 2003.

  (65) Iemitsu M, Miyauchi T, Maeda S, Sakai S, Fujii N, Miyazaki H, Kakinuma Y, Matsuda M, Yamaguchi I.  Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.  Hypertension Research 26: 829-837, 2003.

  (66) Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, Ajisaka R, Yamaguchi I, Matsuda M.  Aerobic exercise training reduces plasma endothelin-1 concentration in older women. Journal of Applied Physiology 95: 336-341, 2003.

  (67) Tanabe T, Maeda S, Miyauchi T, Iemitsu M, Takanashi M, Irukayama-Tomobe Y, Yokota T, Ohmori H, Matsuda M.  Exercise training improves ageing-induced decrease in eNOS expression of the aorta.  Acta Physiologica Scandinavica 178: 3-10, 2003.

  (68) Miyauchi T, Maeda S, Iemitsu M, Kobayashi T, Kumagai Y, Yamaguchi I, Matsuda M.  Exercise causes a tissue-specific change of NO production in the kidney and lung.  Journal of Applied Physiology 94: 60-68, 2003.

  (69) Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Irukayama-Tomobe Y, Goto K, Yamaguchi I, Matsuda M.  Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: An endothelin receptor antagonist reduces the redistribution   Circuration 106: 2188-2193, 2002.

  (70) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I.  Aging-induced decrease in the PPAR-α level hearts is improved by exercise training.  American Journal of Physiology Heart and Circulatory Physiology 283: H1750-H1760, 2002.

  (71) Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Yokota T, Goto K, Yamaguchi I, Matsuda M.  Effects of exercise training on gene expression of endothelin-1 mRNA in the aorta of aged rat.  Clinical Science 103: 118S-123S, 2002.

  (72) Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Irukayama-Tomobe Y, Goto K, Matsuda M, Yamaguchi I.  Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart.  Clinical Science 103: 152S-157S, 2002.

  (73) Iemitsu M, Miyauchi T, Maeda S, Sakai S, Kobayashi T, Fujii N, Miyazaki H, Matsuda M, Yamaguchi I.  Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat.  American Journal of Physiology Regulatory, Integrative and Comparative Physiology 281: R2029-R2036, 2001.

  (74) Maeda S, Miyauchi T, Kakiyama T, Sugawara J, Iemitsu M, Irukayama-Tomobe Y, Murakami H, Kumagai Y, Kuno S, Matsuda M.  Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans.  Life Sciences 69: 1005-1016, 2001.

  (75) Iemitsu M, Itoh M, Fujimoto T, Tashiro M, Nagatomi R, Ohmori H, Ishii K.  Regional cardiac glucose metabolism during running measured by 3D positron emission tomography in humans.   Advances in Exercise and Sports Physiology 7: 53-58, 2001.

  (76) Iemitsu M, Itoh M, Fujimoto T, Tashiro M, Nagatomi R, Ohmori H, Ishii K.  Whole-body energy mapping under physical exercise using positron emission tomography.  Medicine & Science in Sports & Exercise 32: 2067-2070, 2000.

  (77) Iemitsu M, Miyauchi T, Maeda S, Yuki K, Kobayashi T, Kumagai Y, Shimojo N, Yamaguchi I, Matsuda M.  Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts.  American Journal of Physiology Regulatory, Integrative and Comparative Physiology 279: R951-R959, 2000.

  (78) Maeda S, Miyauchi T, Sakai S, Kobayashi T, Iemitsu M, Goto K, Sugishita Y, Matsuda M.  Prolonged exercise causes an increase in endothelin-1 production in the heart in rats.  American Journal of Physiology Heart and Circulatory Physiology 275: H2105-H2112, 1998.

  (79) Miyachi M, Iemitsu M, Okutsu M, Onodera S.  Effects of endurance training on the size and blood flow of the arterial conductance vessels in humans.  Acta Physiologica Scandinavia 163: 13-16, 1998.