The innate immune cells called phagocytes play an essential role in host defense against pathogens. However, when dysregulated, phagocytes cause host damage and inflammatory diseases. Nakayama Lab is focused on understanding the molecular mechanisms by which phagocytes such as macrophages, dendritic cells, and neutrophils recognize and engulf pathogenic particles such as apoptotic cells, microbes, and crystals. Our research will hopefully open the way to new intervention strategies to prevent or cure inflammatory diseases caused by dysregulated phagocyte systems.