• Hori A,Toyoura S, Fujiwara M, Taniguchi R,Kano Y, Yamano T, Hanayama R, and Nakayama M.
    MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C.
    iScience published online, 2024
  • Yamaguchi S-I, Xie Q, Ito F, Terao K, Kato Y, Kuroiwa M, Omori S, Taniura H, Kinoshita K, Takahashi T, Toyokuni S, Kasahara, K, and Nakayama M.
    Carbon nanotube recognition by human Siglec-14 provokes inflammation.
    Nature Nanotechnol. 18,628-636, 2023
    This paper is highlighted in the News and Views in the same issue of Nature Nanotechnology. .
  • Kuroiwa M, Yamaguchi S-I, Kato Y, Hori A, Toyoura S, Nakahara M, Morimoto N, and Nakayama M.
    Tim4, a macrophage receptor for apoptotic cells, binds polystyrene microplastics via aromatic-aromatic interactions.
    Sci. Total Environ. 875, 162586, 2023
  • Nakayama M, Hori A, Toyoura S, and Yamaguchi SI.
    Shaping of T Cell functions by Trogocytosis
    Cells 10, 1155, 2021
  • Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi, S-I, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, and Nakayama M.
    Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.
    Cell Rep. 34, 108734, 2021
  • Kawashima M, Carreras J, Higuchi H, Kotaki R, Hoshina T, Okuyama K, Suzuki N, Kakizaki M, Miyatake Y, Ando K, Nakayama M, Umezu S, Horie R, Higuchi Y, Katagiri K, Goyama S, Kitamura T, Chamoto K, Yano S, Nakamura N, and Kotani A.
    PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.
    Leukemia 34, 2405-2417, 2020.
  • Nakayama M.
    Macrophage recognition of crystals and nanoparticles.
    Front. Immunol. 9, 103, 2018
  • Morimoto N, Takei R, Wakamura M, Oishi Y, Nakayama M, Suzuki M, Yamamoto M, and Winnik FM.
    Fast and effective mitochondrial delivery of omega-Rhodamine-B-polysulfobetaine-PEG copolymers.
    Sci. Rep. 8, 1128, 2018
  • Tsugita M, Morimoto N, Tashiro M, Kinoshita K, and Nakayama M.
    SR-B1 is a silica receptor that mediates canonical inflammasome activation.
    Cell Rep. 18, 1298-1311, 2017
    This article was selected by the Faculty of 1000 as an article of special significance in biology and medicine.
  • Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, and Smyth MJ.
    IFN-g is required for cytotoxic T cell-dependent cancer genome immunoediting.
    Nature Commun. 8:14607, 2017
  • Tsugita M, Morimoto N, and Nakayama M.
    SiO2 and TiO2 nanoparticles synergistically trigger macrophage inflammatory responses.
    Part. Fibre. Toxicol. 14:11, 2017
  • Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma, S, and Miyake S.
    Cutting Edge: Anti-TIM-3 treatment exacerbate pulmonary inflammation and fibrosis in mice.
    J. Immunol. 199, 3733-3737, 2017
    This article was selected by the Faculty of 1000 as an article of special significance in immunology.
  • Funamoto K, Yoshino D, Matubara K, Zervantonakis IK, Funamoto K, Nakayama M, Masamune J, Kimura Y, and Kamm RD.
    Endothelial monolayer permeability under controlled oxygen tension.
    Integr. Biol (Camb). 19, 529-538, 2017
  • Morimoto N, Wakamura M, Muramatsu K, Toita S, Nakayama M, Shoji W, Suzuki M, and Winnik FM.
    Membrane translocation and organelle-selective delivery steered by polymeric zwitterionic nanospheres.
    Biomacromolecules. 17, 1523-1535, 2016
  • Sonofuchi K, Hagiwara Y, Koizumi Y, Chiba A, Kawano M, Nakayama M, Ogasawara K, Yabe Y, and Itoi E.
    Quantitative in vivo biocompatibility of new ultralow-nickel cobalt-chromium-molybdenum alloys.
    J. Orthop. Res. 34, 1505-1513, 2016
  • Nakayama M.
    Antigen presentation by MHC-dressed cells.
    Front. Immunol. 5, 672, 2015
  • Kusaka T, Nakayama M, Nakamura K, Ishimiya M, Furusawa E, and Ogasawara K.
    Effect of silica particle size on macrophage inflammatory responses.
    PLoS ONE. 9, e92634, 2014
  • Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, and Ogasawara K.
    NKG2D+ IFN-g+ CD8+ T cells are responsible for palladium allergy.
    PLoS ONE. 9, e86810, 2014
  • Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y Suzuki R and Ogasawara K.
    NKG2D functions as an activating receptor on natural killer cells in the common marmoset (Callithrix jacchus).
    Int. Immunol. 11, 597-606, 2014
  • Nakamura K, Nakayama M, Kawano M, Amagai R, Ishii T, Harigae H, and Ogasawara K.
    Fratricide of naturel killer cells dressed with tumor-derived NKG2D ligand.
    Proc. Natl. Acad. Sci. U. S. A. 110, 9421-9426, 2013
  • Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, and Najafian N.
    Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.
    J. Immunol. 191, 4447-4455, 2013
  • Nakamura K, Nakayama M, Kawano M, Ishii T, Harigae H, and Ogasawara K.
    NK-cell fratricide: Dynamic crosstalk between NK and cancer cells.
    Oncoimmunology. 2, e26529, 2013
  • Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, and Ogasawara K.
    Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence.
    J. Immunol. 189, 5903-5911, 2012
    This article was selected by the Faculty of 1000 as an article of special significance in immunology.
  • Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, and Ogasawara K.
    Natural Killer (NK)-dendritic cell interactions generate MHC Class II-dressed NK cells that regulate CD4+ T cells.
    Proc. Natl. Acad. Sci. USA. 108, 18360-18365, 2011
    This article was selected by the Faculty of 1000 as the top 2% of published articles in biology and medicine.
  • Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, and Yagita H.
    Importin beta1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.
    J. Biol. Chem. 286, 43383-43393, 2011
  • Takeda K, Nakayama M, Sakaki M, hayakawa Y, Imawari M, Ogasawara K, Okumura K, and Smyth MJ.
    IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice.
    J. Leukoc. Biol. 90, 777-785, 2011
  • Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, and Okumura K.
    Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation.
    Blood 113, 3821-3830, 2009
  • Ebihara N, Nakayama M, Tokura T, Ushio H, and Murakami A.
    Expression and function of fibroblast growth factor-inducible 14 human corneal myofibroblasts.
    Exp. Eye Res. 89, 256-262, 2009
  • Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, and Murakami A.
    Proinflammatory effect of TWEAK/Fn14 interaction in human retinal pigment epithelial cells.
    Curr. Eye Res. 34, 836-844, 2009
  • Nakajima A, Kojima Y, Nakayama M, Yagita H, Okumura K, and Nakano H.
    Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells.
    Oncogene 27, 76-84, 2008
  • Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, and Aderem A.
    Paired immunoglobulin-like receptors bind to bacteria and shape TLR-mediated cytokine production.
    J. Immunol. 178, 4259-4350,2007
  • Kaduka Y, Takeda K, Nakayama M, Kinoshita K, Yagita H, and Okumura K.
    TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.
    Biochem. Biophys. Res. Commun. 331, 384-390, 2005
  • Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, and Ogawa H.
    Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.
    J. Invest. Dermatol. 122,1175-1179, 2004
  • Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, and Yamaoka S.
    TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.
    J. Biol. Chem. 278, 36005-36012, 2003
  • Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, and Yagita H.
    Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.
    J. Immunol. 170, 341-348, 2003
  • Nakayama M, Harada N, Okumura K, and Yagita H.
    Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies.
    Biochem. Biophys. Res. Commun.306, 819-825, 2003
  • Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, and Okumura K.
    Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.
    Biochem. Biophys. Res. Commun. 306, 819-825, 2003
  • Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, and Yagita H.
    Multiple pathways of TWEAK-induced cell death.
    J. Immunol. 168, 734-743, 2002
  • Nakayama M, Kayagaki N, Yamaguchi N, Okumura K, and Yagita H.
    Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity.
    J. Exp. Med. 192, 1373-1380, 2000
  • Nagao F, Nakayama M, Muto T, and Okumura K.
    Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects.
    Biosci. Biotechnol. Biochem. 64, 2706-2708, 2000
  • Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, Okamura H, NakanishiK, Okumura K, and Yagita H.
    Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.
    J. Immunol. 163, 1906-1913, 1999
  • Kayagaki N, Yamaguchi N, Nakayama M, Eto H, Okumura K, and Yagita H.
    Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
    J. Exp. Med. 189, 1451-1460, 1999
  • Kayagaki N, Yamaguchi N, Nakayama M, Kawasaki A, Akiba H, Okumura K, and Yagita H.
    Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.
    J. Immunol. 162, 2639-2647, 1999
  • Degawa M, Nakayama M, Konno Y, Masubuchi K, and Yamazoe Y.
    2-Methoxy-4-nitroaniline and its isomers induce cytochrome P4501A (CYP1A) enzymes with different selectivities in the rat liver.
    Biochim. Biophys. Acta.1379, 391-398, 1998
  • Uehara N, Iwahori Y, Asamoto M, Baba-Toriyama H, Iigo M, Ochiai M, Nagao M, Nakayama M, Degawa M, Matsumoto K, Hirono I, Beppu H, Fujita K, and Tsuda H.
    Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe.
    Jpn. J. Cancer Res.(Cancer Sci.) 87, 342-348, 1996
  • Degawa M, Nakayama M, Yoshinari K, and Hashimoto Y.
    2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver.
    Cancer Lett.96, 95-98, 1995


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